Table 3. Patient mortality in STMN1(+) colorectal cancer compared with STMN1(-) tumor in strata of BMI category.
| BMI category | Colorectal cancer–specific mortality in STMN1 + tumors (vs. STMN1(−) tumors as a referent) | Overall mortality in STMN1 + tumors (vs. S(−) tumors as a referent) | ||||
|---|---|---|---|---|---|---|
| No. of deaths/cases (STMN1 + vs. −) | Stage-matched HR (95% CI) | Multivariate HR (95% CI) | No. of deaths/cases (STMN1 + vs. −) | Stage-matched HR (95% CI) | Multivariate HR (95% CI) | |
| <25 kg/m2 | 34/130 vs. 28/99 | 0.49 (0.29–0.84) | 0.31 (0.17–0.56) | 61/130 vs. 43/99 | 0.75 (0.50–1.13) | 0.56 (0.36–0.86) |
| 25–30 kg/m2 | 21/107 vs. 28/100 | 0.79 (0.44–1.42) | 0.56 (0.29–1.08) | 34/107 vs. 46/100 | 0.80 (0.51–1.26) | 0.65 (0.40–1.06) |
| ≥30 kg/m2 | 13/45 vs. 12/39 | 1.55 (0.68–3.49) | 1.94 (0.77–4.90) | 20/45 vs. 18/39 | 1.41 (0.73–2.74) | 1.70 (0.82–3.52) |
BMI, body mass index; CI, confi dence interval; HR, hazard ratio.
The multivariate Cox model included the STMN1 variable stratified by BMI category, age, year of diagnosis, sex, family history of colorectal cancer, tumor location, stage, grade, KRAS, BRAF, PIK3CA, p53, p21, p27, cyclin D1, β-catenin, COX-2, FASN, LINE-1 methylation, microsatellite instability (MSI), and CpG island methylator phenotype (CIMP). SAS codes to stratify the STMN1 variable by BMI category are available upon request.
P for interaction between STMN1 and BMI = 0.005 (when the BMI category was used as linear ordinal variable), and 0.011 (when BMI was used as a dichotomous variable; < 30 vs. ≥30 kg/m2) in analysis of cancer-specific mortality.