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. 2009 Dec 22;118(5):627–634. doi: 10.1289/ehp.0901510

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AMPK inactivation causes As-induced inhibition of neurite outgrowth. (A) Effect of pretreatment with 4 mM AICAR or 20 μM CC (or transfection with CA-AMPK or DN-AMPK on neurite outgrowth in differentiating N2a cells exposed to RA or RA plus 3 μM As for 48 hr. Blots show the efficiency of CC, ACAR, DN-AMPK, and CA-AMPK on the activation of AMPK using the expression of p-ACC and c-myc. Images represent typical fields of cells viewed with an inverted light microscope; bars = 100 μm. (B) Percentage of cells exhibiting neurites (left) and average neurite length (right) in 200 cells. Each data point is the mean ± SE of three independent experiments.

*p <0.05 compared with RA treatment alone. ^#p < 0.05 compared with RA plus As-treatment.