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. 2009 Dec 22;118(5):627–634. doi: 10.1289/ehp.0901510

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Arsenic inhibits LKB1 activation. N2a cells were treated with RA or RA plus 3 μM As. Immunoblots showing expression of LKB1 and p-LKB1(Ser428) (A) and effect of As on p-LKB1(Ser428) distribution (B) in N2a cells at five time points; GADPH and lamin A/C served as loading controls of cytoplasm and nucleus, respectively. (C) Effect of As on localization of p-LKB1(Ser428) in N2a cells treated for 24 hr. Immunofluorescence indicates expression of p-LKB1(Ser428) as green, and nuclei (blue) were visualized with DAPI staining. (D) Effect of As on LKB1/MO25/STRAD interaction in treated N2a cells at four time points. IP, immunoprecipitated.