Figure 1.
Covalent reactive metabolite binding to protein in rat, rhesus, and mouse tissue. Abbreviations: ethmo, ethmoturbinate; Maj D, major daughter; max, maxilloturbinate; Min D, minor daughter. Fresh samples of rat septum (n = 3), rat olfactory ethmoturbinate (n = 3), rhesus maxilloturbinate (n = 8), and rhesus ethmoturbinate (n = 8) were incubated with 14C-naphthalene (250 μM) for 2 hr at 37°C for determination of the levels of covalent reactive metabolite binding to protein. Values are mean ± SD. Reference values for tissue subcompartments of mouse lung are from Cho et al. (1994).