Table 6.
Association (95% CIs) between prenatal exposure to BDE-153 and indices of neurodevelopment at 12, 24, 36, 48, and 72 months of age.
Model 2b |
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Age (months) | n | Univariate Change in score per ln-unit | Model 1a Change in score per ln-unit | Change in score per ln-unit | Change in score per increase from the 25th to 75th percentile (IQRc) | |
MDI | 12 | 111 | −0.24 (−1.74 to 1.26) | 0.05 (−1.59 to 1.69) | 0.02 (−1.65 to 1.68) | 0.02 (−1.51 to 1.54) |
24 | 113 | −0.42 (−2.90 to 2.06) | −1.26 (−3.68 to 1.17) | −1.71 (−4.07 to 0.65) | −1.57 (−3.73 to 0.60) | |
36 | 107 | 1.78 (−0.54 to 4.09) | 0.29 (−2.17 to 2.75) | −0.05 (−2.46 to 2.37) | −0.05 (−2.25 to 2.17) | |
PDI | 12 | 111 | −1.44 (−3.65 to 0.77) | −2.02 (−4.37 to 0.33) | −1.95 (−4.34 to 0.43) | −1.79 (−3.98 to 0.39) |
24 | 111 | 0.90 (−1.12 to 2.92) | 1.20 (−1.03 to 3.44) | 1.21 (−1.06 to 3.49) | 1.11 (−0.97 to 3.20) | |
36 | 102 | −0.04 (−2.62 to 2.54) | 0.04 (−2.96 to 3.05) | 0.03 (−3.00 to 3.05) | 0.03 (−2.75 to 2.79) | |
Full | 48 | 97 | −0.30 (−3.14 to 2.55) | −2.69 (−5.17 to −0.21)* | −3.09 (−5.64 to −0.54)* | −2.83 (−5.17 to −0.49)* |
72 | 92 | 0.02 (−3.28 to 3.32) | −3.40 (−6.57 to −0.22)* | −3.25 (−6.35 to −0.15)* | −2.98 (−5.82 to −0.14)* | |
Verbal | 48 | 97 | 0.24 (−2.63 to 3.12) | −1.93 (−4.71 to 0.85) | −2.46 (−5.32 to 0.41) | −2.25 (−4.87 to 0.38) |
72 | 92 | 1.74 (−1.82 to 5.29) | −1.91 (−5.28 to 1.47) | −1.79 (−5.05 to 1.47) | −1.64 (−4.63 to 1.35) | |
Performance | 48 | 97 | −1.22 (−4.37 to 1.92) | −3.46 (−6.36 to −0.57)* | −3.62 (−6.62 to −0.63)* | −3.32 (−6.07 to −0.58)* |
72 | 92 | −2.03 (−5.23 to 1.17) | −4.35 (−7.63 to −1.06)* | −4.19 (−7.48 to −0.89)* | −3.84 (−6.85 to −0.82)* |
Model 1 adjusted for age at testing, race/ethnicity, IQ of mother, sex of child, gestational age at birth, maternal age, ETS (yes/no), maternal education, material hardship, and breast-feeding.
Model 2 adjusted for all covariates in model 1 plus language and location of interview.
IQR for BDE-153 is 0.85 ng/g lipid.
CIs do not include 0.00.