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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Dev Biol. 2010 Mar 24;342(1):63–73. doi: 10.1016/j.ydbio.2010.03.009

Figure 2.

Figure 2

Morphology and epiblast length of Cripto; Cryptic double mutants relative to wild-type, Cripto, and Nodal null mutants. (A–E) Embryos of the indicated genotypes at 5.5 dpc; dashed lines indicate boundary between epiblast and visceral endoderm. (G–K) Embryos of the indicated genotypes at 6.5 dpc; arrows in I–K indicate regions of thickened visceral endoderm. (M–Q) Embryos of the indicated genotypes at 7.5 dpc; arrow in N indicates expanded neuroectoderm that is typical of Cripto−/− mutants (Ding et al., 1998). Scale bars correspond to 100 microns. (F, L, R) Box and whiskers plot of embryo length, measured from the base of the ectoplacental cone to the distal tip, in embryos of the indicated genotypes at 5.5, 6.5 and 7.5 dpc. Embryos of Cripto−/−; Cryptic−/− and Cripto−/−; Cryptic+/− genotypes are grouped together as Cripto; Cryptic. Abbreviations: ave, anterior visceral endoderm; epc, ectoplacental cone; epi, epiblast; exe, extraembryonic ectoderm; ps, primitive streak; ve, visceral endoderm.