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. Author manuscript; available in PMC: 2011 May 17.
Published in final edited form as: FEBS Lett. 2009 Nov 26;584(10):2022–2027. doi: 10.1016/j.febslet.2009.11.078

Fig. 2. Orai1 C terminus potently opens Orai2 and Orai3.

Fig. 2

The CRAC current was measured in HEK cells transfected with the indicated chimera. (ai) shows the current mediated by Orai2-Orai1CT and STIM1 (●) or SOAR (○). The gray trace shows an example of a typical current mediated by Orai2+STIM1. (aii) shows examples I/V for Orai2-Orai1CT with STIM1 (red) and SOAR (purple). (bi) shows the current mediated by Orai3-Orai1CT and STIM1 (●) or SOAR (○). The gray trace shows an example of a typical current mediated by Orai3+STIM1. (bii) shows examples I/V for Orai3-Orai1CT with STIM1 (blue) and SOAR (green). (ci) shows the I/V of the current recorded in cells transfected with STIM1 and Orai3 (blue) or Orai3-Orai1CT (red) activated by 50 μM 2-ABP and (cii) shows the meam±s.e.m of 4 experiments at each condition. (d) is the mean±s.e.m of 4–6 experiments of the current density recorded under the indicated conditions. * denotes p<0.01 relative to the respective control. (Reproduced from [30]).