Absolute retention of 99mTc-NC100692 (%ID/g) within myocardium was determined by GWC.
(A) 99mTc-NC100692 retention in IGF-1 (n=5) and lacZ-control (n=3) rats at 4 weeks post-MI. There was a significant increase in retention of 99mTc-NC100692 within infarct territory of all animals compared to remote segments. This increase in 99mTc-NC100692 was significantly higher in IGF-1 animals than in lacZ-controls. This trend was true for all myocardial territories.
(B) 99mTc-NC100692 retention at 16 weeks post-MI was significantly reduced in IGF-1 animals (n=5) compared to lacZ rats (n=6). The trend for increased 99mTc-NC100692 retention in IGF-1 treated rats was also observed in border and remote regions.
*P<0.05 vs. lacZ, †P<0.05 vs. remote