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. Author manuscript; available in PMC: 2011 May 10.
Published in final edited form as: J Comb Chem. 2010 May 10;12(3):315–317. doi: 10.1021/cc9001907

Scheme 1.

Scheme 1

(a) BH3-THF, 65°C, 4 days; (b) piperidine, 65°C, overnight; (c) 6 equiv. Fmoc-NCS in DMF (0.3 M), RT, overnight; (d) 20% piperidine/DMF; (e) 20 equiv. α– halogenoketones in DMF (0.3 M), 70°C, overnight; (f) HF/anisole, 0°C, 90 min.