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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Dec 16;48(6):1146–1156. doi: 10.1016/j.yjmcc.2009.12.004

Figure 2.

Figure 2

Bnip3-mediated swelling and cytochrome c release are not inhibited by the mPTP inhibitor cyclosporine A. A. Incubation of mitochondria with 1 μM CsA inhibits swelling mediated by 250 μM Ca2+. B. CsA has no effect on swelling mediated by Bnip3 (1 μg). C. Bnip3 (1 μg) and Ca2+ (250 μM) induce release of cytochrome c from isolated mitochondria. CsA (1 μM) reduces Ca2+-mediated cytochrome c release but has no effect on Bnip3-mediated release. Western blot is representative of three independent experiments. D. Isolated mitochondria were treated with 0, 0.1, 0.5, or 1 μg Bnip3 in the presence or absence of 1 μM CsA.