Skip to main content
. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Eur J Pharmacol. 2010 Mar 31;636(1-3):114–120. doi: 10.1016/j.ejphar.2010.03.028

Fig. 4. Inhibition of statin post-treatment-induced protection by mevalonate and geranylgeranyl pyrophosphate (GGPP).

Fig. 4

Bovine pulmonary arterial endothelial cells were exposed to or not exposed to a 5-h oxygen-glucose deprivation (OGD) and 1-h simulated reperfusion. The cells were posttreated with or without 2 µM simvastatin or 4 µM atorvastatin in the presence or absence of various concentrations of mevalonate or GGPP for 1 h immediately after the OGD. Results are means ± S.D. (n = 15 to 47 for panel A, 18 to 47 for panel B, 12 to 45 for panel C and 12 to 45 for panel D). * P < 0.05 compared with control. ^ P < 0.05 compared with OGD only. # P < 0.05 compared with OGD + statin post-treatment.