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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jan 12;48(6):1060–1070. doi: 10.1016/j.yjmcc.2009.11.020

Figure 2. Netrin-1 protects heart from ischemia/reperfusion injury.

Figure 2

Hearts were pre-perfused for 45 min with netrin-1 (100 ng/ml) before ischemia/reperfusion (20 min ischemia, 60 min reperfusion with netrin-1). Sections of hearts were stained with 2,3,5-TTC and infarct area calculated as % of risk area. (A) Infarct size was significantly decreased in netrin-1 treated hearts from that of controls (21.8±4.9% vs. 42.5±3.6%, respectively, p<0.01); (B) Infarct size shown in quantitative grouped data (Means±SEM, n=5), * p<0.01. (C) Representative ESR spectra of NO• production from hearts perfused with netrin-1; (D) Grouped data from four independent experiments. * p<0.05;