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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jan 4;48(6):1169–1179. doi: 10.1016/j.yjmcc.2009.12.019

Figure 3. In vivo KChIP2 expression alters cardiomyocyte mechanics.

Figure 3

KChIP2 effects on cardiomyocyte contractility and Ca2+ transients were determined in cardiomyocytes isolated from banded hearts infected with β-gal or KChIP2 in the presence of 1–10 mM Ca2+ compared to sham hearts., overexpression of KChIP2 significantly decreased cell shortening (A, n=25), velocities of contraction (B, n=25) and relaxation (C, n=25) and induced shorter Ca2+ amplitudes (D, n=21) compared to β-gal (data shown at 4 mM Ca2+). * P< 0.01 Ad.β-gal vs. Sham; § P<0.04, Ad.KChIP2 vs. Ad.β-gal.