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Correlation between the responses of PGi neurons to a single dose of morphine and that during the naltrexone-precipitated withdrawal from chronic morphine infusion (black circle, and black line, R=0.73, R2=0.53, P<0.0001). In the control groups, there was no significant correlation between the response of PGi neurons to a single dose of morphine and that to naltrexone after chronic saline infusion (R = 0.17, R2 = 0.03, P>0.2, grey circles and grey line).
