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DEX prevents salmeterol-induced changes in agonist responsiveness in rabbit ASM tissues. Relative to controls, ASM tissues exposed to salmeterol exhibit significantly increased contractility to ACh (A) and impaired relaxation to isoproterenol (B). Pre-treatment with either rolipram or DEX prevents the salmeterol-induced changes in ASM responsiveness. Data represent mean ± SE values from 6-7 experiments. ANOVA used for multiple comparisons of mean Tmax values.
