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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Apr 14;125(5):1020–1027. doi: 10.1016/j.jaci.2010.02.007

Figure 6.

Figure 6

MKP-1 siRNA prevents DEX-induced suppression of the proasthmatic effects of salmeterol on ASM responsiveness. Rabbit ASM tissues exposed to salmeterol exhibit significantly increased contractility to ACh (A) and impaired relaxation responses to isoproterenol (B) that are prevented by pretreatment with DEX. The protective effects of DEX are abrogated in salmeterol-exposed tissues transfected with MKP-1 siRNAs. Data are mean ± SE values from 5-7 paired experiments. ANOVA used for multiple comparisons of mean Tmax values.