Fig. 6.

Schematic representation of heat stress-induced signaling events leading to the increased expression of Hsp70 and MnSOD. Heat shock induces an enhancement of cellular ROS levels which in turn is responsible for the augmentation of p38MAPK activation. In heat-stressed V79 fibroblasts, Akt is also phosphorylated, and this is controlled by p38MAPK. Activated Akt functions upstream of the overexpression of both Hsp70 and MnSOD