Figure 1.

Incidence rate ratios* and 95% confidence intervals of second solid cancers among ≥5 year survivors of uterine corpus cancer (UCC). Secondary tumor sites are categorized by estimated irradiated dose^† (heavily-, moderately-, and lightly-irradiated sites) following UCC radiotherapy.

^* Incidence Rate Ratios are from Poisson regression analysis stratified for age at UCC diagnosis, calendar year of diagnosis, cancer registry, and race. Patients treated with surgery only form the reference group

^† Heavily-irradiated sites (estimated radiation doses ≥5 Gy)includes: bone (pelvic bones, sacrum, coccyx and associated joints), colon (ascending, descending, cecum, sigmoid, and transverse), rectum, small intestine, soft tissue (connective, subcutaneous and other soft tissues of abdomen, connective, subcutaneous, and other soft tissues of pelvis, connective, subcutaneous, and other soft tissues of trunk), urinary bladder and ureter. Moderately-irradiated sites (0.4–5 Gy) includes: bone (vertebral column, and rib, sternum, clavicle, and associated joints), colon (other sites than in heavy irradiated sites), gall bladder, kidney, liver, pancreas, renal pelvis, and stomach. Lightly-irradiated sites (<0.4 Gy) includes: all solid sites except the sites defined in the heavily- and moderately-irradiated sites above. The brachytherapy analysis has a different site exposure classification compared to the other radiotherapy groups (ascending, descending, and transverse colon are classified as moderately-irradiated sites, and vertebral column and rib, sternum, clavicle, and associated joints are classified as lightly-irradiated sites).