Table 1.
Estimated organ specific doses (in gray) for specific locations after radiotherapy for uterine corpus cancer.
| Location | Combination Radiotherapy* | External beam therapy† | Location | Brachytherapy‡ | |||
|---|---|---|---|---|---|---|---|
| Average | Range | Average | Range | Average | Range | ||
| Heavily-irradiated sites§ | Heavily-irradiated sites§ | ||||||
| Small intestine | 45 | 11 – 70 | 40 | 10 – 50 | Small intestine | 5.0 | 1.0 – 20 |
| Colon | Colon | ||||||
| Ascending | 45 | 10 – 54 | 43 | 9.0 – 50 | Cecum | 5.0 | 4.0 – 6.5 |
| Descending | 24 | 1.5 – 54 | 23 | 1.2 – 50 | Sigmoid | 20 | 15 – 35 |
| Transverse | 9.4 | 4.2 – 18 | 8.2 | 3.6 – 16 | Rectum | 35 | 20 – 60 |
| Sigmoid | 25 | 20 – 40 | 50 | 49 – 51 | Ureter | 5.2 | 1.0 – 9.0 |
| Cecum | 55 | 53 – 57 | 50 | 49 – 51 | Urinary bladder | 35 | 20 – 60 |
| Rectum | 40 | 25 – 65 | 50 | 49 – 51 | Bone¶ | 10 | 5 – 20 |
| Ureter | 45 | 9.7 – 59 | 40 | 8.7 – 50 | Soft tissue# | 6.5 | 0.50 – 20 |
| Urinary bladder | 40 | 25 – 65 | 50 | 49 – 51 | |||
| Bone¶ | 60 | 55 – 70 | 50 | 49 – 51 | Moderately-irradiated sites§ | ||
| Soft tissue# | 40 | 2.2 – 70 | 34 | 1.7 – 50 | Colon | ||
| Active bone marrow | 20 | 19 – 22 | 19 | 18 – 20 | Ascending | 1.8 | 1.0 – 3.7 |
| Descending | 1.2 | 0.30 – 3.7 | |||||
| Moderately-irradiated sites§ | Transverse | 1.2 | 0.60 – 1.7 | ||||
| Stomach | 4.1 | 0.80 – 25 | 3.4 | 0.60 – 23 | Stomach | 0.70 | 0.20 – 1.8 |
| Liver | 2.3 | 1.9 – 4.9 | 1.9 | 1.7 – 4.0 | Liver | 0.40 | 0.20 – 0.90 |
| Gall bladder | 3.3 | 1.7 – 4.8 | 2.6 | 1.3 – 3.7 | Gall bladder | 0.70 | 0.40 – 1.1 |
| Pancreas | 2.0 | 1.5 – 3.7 | 1.5 | 1.2 – 3.0 | Pancreas | 0.50 | 0.30 – 0.70 |
| Kidney | 3.4 | 1.4 – 6.3 | 2.8 | 1.1 – 5.4 | Kidney | 0.60 | 0.30 – 0.85 |
| Renal pelvis | 3.2 | 3.0 – 3.4 | 2.6 | 2.5 – 2.7 | Renal pelvis | 0.60 | 0.50 – 0.70 |
| Bone** | 0.52 | 0.10 – 2.5 | 0.40 | 0.06 – 2.0 | Active bone marrow | 1.3 | 1.0 – 1.6 |
| Lightly-irradiated sites§ | Lightly-irradiated sites§ | ||||||
| Buccal cavity, pharynx | 0.37 | 0.31 – 0.42 | 0.35 | 0.30 – 0.40 | Buccal cavity, pharynx | 0.02 | 0.01 – 0.02 |
| Lung and bronchus | 0.30 | 0.16 – 0.45 | 0.20 | 0.10 – 0.30 | Lung and bronchus | 0.10 | 0.06 – 0.15 |
| Breast | 0.30 | 0.22 – 0.37 | 0.20 | 0.15 – 0.25 | Breast | 0.09 | 0.07 – 0.12 |
| Thyroid | 0.08 | 0.06 – 0.10 | 0.05 | 0.04 – 0.06 | Bone** | 0.12 | 0.04 – 0.50 |
| Thyroid | 0.03 | 0.02 – 0.04 | |||||
Combination therapy (external beam therapy plus brachytherapy) doses were estimated assuming 50 gray (Gy) Tumor Dose (TD) to midline of the pelvis with Anterior-Posterior/Posterior-Anterior (AP/PA) fields 20 × 20 cm2, with central blocking and with 5000 mgh radium equivalent Tandem or Heyman capsules with ovoids brachytherapy.
External Beam therapy doses were estimated assuming 50 Gy TD to midline of the pelvis, AP/PA fields 20 × 20 cm2 (open field) 6 megavoltage (MV) photons.
Brachytherapy doses were estimated assuming 5000 mgh Radium equivalent, Tandem or Heyman capsules with ovoids.
Heavily-, moderately-, and lightly-irradiated sites were defined as those sites with estimated radiation doses ≥5, 0.4–5, and <0.4 Gy, respectively.
Heavily-irradiated bone sites include the pelvic bones, sacrum, coccyx and associated joints.
Heavily-irradiated soft tissue sites include the abdomen; pelvis; and trunk soft tissues.
Include the ribs, sternum, and clavicle.