Table 4.

Sequences for which the effect of temperature was dependent on diagnosis in the ANCOVA analysis

Affymetrix ID	Common name(s)	ANCOVA P value for:			Note
		Diagnosis (noninfectious SIRS vs. sepsis)	Diagnosis × temperature	Temperature
205242_at	Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) (CXCL13)	0.026	0.025	0.535*
202865_at	DnaJ (Hsp40) homolog, subfamily B, member 12 (DNAJB12)	0.051*	0.050	0.502*
206782_s_at	DnaJ (Hsp40) homolog, subfamily C, member 4 (DNAJC4)	0.019	0.019	0.007
223000_s_at	F11 receptor (F11R)	0.046	0.044	0.527*
215363_x_at	Folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1)	0.050	0.048	0.875*
211220_s_at	Heat shock transcription factor 2 (HSF-2)	0.037	0.036	0.589*
200799_at	Heat shock 70 kD protein 1A (HSPA1A); HSP 70-1A	0.030	0.035	0.106*	(3,4)
202581_at	Heat shock 70 kDa protein 1B (HSPA1B); HSP 70-1B	0.025	0.027	0.285*	(3,4)
210189_at	Heat shock 70 kDa protein 1-like (HSPA1L)	0.042	0.047	0.442*
202859_x_at	Interleukin 8 (IL-8); CXC chemokine ligand 8	0.003	0.003	0.045	(2)
214461_at	Lipopolysaccharide binding protein (LBP)	0.029	0.028	0.998*	(1)
210367_s_at	Prostaglandin E synthase (PTGES)	0.034	0.036	0.320*

(1) Serum LBP protein has been reported to be differentially expressed in SIRS vs. sepsis (Prucha et al. 2003); (2) serum IL-8 has been reported to be differentially expressed in SIRS vs. severe sepsis/septic shock (Rodriguez-Gaspar et al. 2001); (3) HSP 70 protein has been reported to be differentially expressed in SIRS vs. sepsis (Adib-Conquy and Cavaillon 2007); (4) HSP 70A1A and A1B mRNA have been reported to show increased expression after exercise (Connolly et al. 2004) and exertional heat injury (Sonna et al. 2004)

*P > 0.05, not statistically significant