Fig. 2.

a Identification of a stimulating epitope within peptide 387–426 and inhibiting epitope within peptide 457–496 using DCs co-stimulated with Hsp70 and with two adjacent or overlapping 20-mer peptides. b Stimulating epitope p407–426 at the base of L3, 4 and L4, 5 loops and the suppressive epitope (p457–496) in the β sheet. c Effect of peptides 407–426 and 457–496 on p38 MAP kinase phosphorylation stimulated by Hsp70 or LPS of lysed DCs by enzyme immunoassay or by Western blotting