Table 1.
The effect of inhibitory peptide (457–496) and stimulating peptide (407–426) on immature DC stimulated with HSP70, CD40LT or LPS
| Percent change | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotype | Immature DC | HSP70 | CD40LT | LPS | ||||||||
| Nil | p457–496 | p407–426 | Nil | p457–496 | p407–426 | Nil | p457–496 | p407–426 | Nil | p457–496 | p407–426 | |
| CD83 | ||||||||||||
| Mean ± SEM | 5.1 ± 0.8 | 4.8 ± 0.4 | 4.9 ± 1.1 | 21.9 ± 1.8 | 15.4 ± 1.8 | 26.6 ± 3.1 | 20.5 ± 2.5 | 11.5 ± .2 | 22.3 ± 2.4 | 17.0 ± 1.6 | 15.8 ± 2.4 | 20.2 ± 1.9 |
| T | 0.6 | 0.18 | 3.56 | 3.49 | 5.68 | 9.28 | 1.15 | 3.69 | ||||
| P | 0.5 | 0.8 | 0.024 | 0.033 | 0.004 | 0.0008 | 0.31 | 0.02 | ||||
Three concentrations of each peptide were used, and the optimum effect on CD83 is presented as mean percent ± SEM and analysed in comparison with untreated (nil) by the paired Student t test (n = 5)