Figure 4.

Difference between surfaces that represent low conservation and high conservation. All the grid points that are occupied in at least 10% of the structures are shown as a green wire grid (low conservation points). All the grid points that represent at least 50% of the structures are shown as a green solid mesh (high conservation points). Both represent an extreme value and are overlaid on the PDB structure 1FK9, depicted with its ligand Efavirenz. The wire grid surface shows all possible side chain locations (low conservation), whereas the solid mesh surface only shows the most conserved side chain location.