Table I.
Volumetric Information Relating the Size of the Consensus Structures to the Size of NNRTIs
| Volumetric object | Volume (Å3) |
|---|---|
| NNRTI consensus (50% occupancy) | 103 |
| NNRTI consensus (30% occupancy) | 296 |
| NNRTI consensus (10% occupancy) | 578 |
| 739W94 | 267 |
| Nevirapine | 274 |
| 1051U91 | 275 |
| Efavirenz | 305 |
| HEPT | 311 |
| Alpha-Apa | 315 |
| PETT2 | 315 |
| PETT1 | 333 |
| HBY097 | 334 |
| MKC442 | 336 |
| UC781 | 341 |
| 9-Chloro-TIBO | 344 |
| 8-Chloro-TIBO | 344 |
| TNK6123 | 364 |
| Rilpivirine | 379 |
| TNK651 | 391 |
| Capravirine | 400 |
| Delavirdine | 432 |
Overview of the volumes contained within the different NNRTI consensus structures compared with the volume of NNRTIs in their bound confirmation as it was obtained from the crystal structure.