Table.
APOA5 −1131T>C genotypes and lipoprotein particle size and concentration in controls in the EPIC-Norfolk Study10
|
Genotype* |
β coefficient (95% CI)† | p value for trend | |||
|---|---|---|---|---|---|
| TT (n=1606) | TC (n=182) | CC (n=7) | |||
| LDL | |||||
| Particle size (nm) | 21·1 (0·6) | 21·0 (0·6) | 20·7 (0·4) | −0·13 (−0·05 to −0·21) | 0·002 |
| Particle concentration (nmol/L) | 1567 (418) | 1680 (461) | 1670 (435) | 105 (44 to 166) | 0·001 |
| VLDL | |||||
| Particle size (nm) | 50·8 (8·4) | 51·3 (7·9) | 59·6 (6·7) | 1·13 (−0·07 to 2·33) | 0·065 |
| Particle concentration (nmol/L) | 93·0 (31·2) | 106·1 (32·4) | 106·6 (23·0) | 12·2 (7·7 to 16·7) | 9·3×10−8 |
| HDL | |||||
| Particle size (nm) | 8·9 (0·5) | 8·8 (0·4) | 8·5 (0·3) | −0·14 (−0·08 to −0·20) | 7·0×10−5 |
| Particle concentration (μmol/L) | 34·0 (5·4) | 33·9 (5·7) | 35·8 (5·4) | 0·04 (−0·7 to 0·8) | 0·93 |
*
Data are mean (SD).
†
Calculated from linear regression of each lipoprotein marker on APOA5 genotype.