Table 1.
Geometric Mean | Min | Median | Max | ||
---|---|---|---|---|---|
Dose | mg/kg | 10.46 | 8.28 | 11.21 | 11.86 |
AUCextrap | % | 2.04 | 1.68 | 1.88 | 2.04 |
AUC0-inf | hr* μg /mL | 13.78 | 11.11 | 13.49 | 16.25 |
AUMC0-inf | hr*hr* μg/mL | 27.12 | 20.03 | 27.29 | 37.38 |
Cl/F | mL/min/kg | 12.65 | 10.55 | 12.11 | 17.70 |
CMAX | μg/mL | 6.74 | 4.48 | 6.80 | 8.88 |
T ½ λz | hr | 0.96 | 0.76 | 0.99 | 1.13 |
λz | /hr | 0.73 | 0.61 | 0.70 | 0.92 |
MRT | hr | 1.97 | 1.69 | 1.85 | 2.70 |
TMAX | hr | 0.85 | 0.50 | 0.63 | 2.00 |
Vz/F | L/kg | 1.05 | 0.86 | 1.04 | 1.57 |