Table 3.

Codeine-6-glucuronide pharmacokinetic parameters after codeine administration to 6 healthy Greyhound dogs.

		IV				Per Os
		Geometric Mean	Min	Median	Max	Geometric Mean	Min	Median	Max
Dose (codeine)	mg/kg	0.734	0.734	0.734	0.734	1.43	1.13	1.53	1.62
AUCextrap	%	11.58	8.18	12.06	15.10	17.41	13.73	16.06	32.25
AUC0-inf	hr* ng/mL	3858.60	2889.75	3853.13	4691.82	8157.80	5929.60	7311.42	14842.15
AUMC0-inf	hr*hr*ng/mL	16184.41	12162.27	16175.49	21476.09	31612.94	22674.87	30850.58	49411.69
Cl/F	mL/min/kg	3.17	2.61	3.19	4.23	3.94	2.38	3.85	5.65
CMAX	ng/mL	735.75	572.00	756.00	919.00	1952.86	1160.00	1675.00	4280.00
T – λz	hr	2.25	1.94	2.28	2.55	1.94	1.70	1.92	2.49
λz	/hr	0.31	0.27	0.30	0.36	0.36	0.28	0.36	0.41
MRT	hr	4.19	3.66	4.25	4.66	3.88	3.33	3.68	5.53
TMAX	hr	1.59	1.00	2.00	2.00	1.62	1.00	1.50	3.00
Vz/F	L/kg	0.62	0.44	0.63	0.84	0.66	0.40	0.61	1.22
Frelative	%					109	90	106	150