. Author manuscript; available in PMC: 2011 Feb 28.

Published in final edited form as: Chem Commun (Camb). 2010 Jan 18;46(8):1241–1243. doi: 10.1039/b923302d

Table 1.

IC₅₀ values of inhibitors and protected inhibitors against MMP-9 and MMP-8 as measured using fluorescence based assay

Inhibitor	IC₅₀	Proinhibitor	IC₅₀	QIC₅₀^a	Enzyme
1	1.02 mM (± 0.03)	2	3.99 mM (± 0.04)	3.9	MMP-9
3	4.03 mM (± 0.05)	4	5.7 mM (± 0.3)	1.4	MMP-9
5	138 μM (± 5)	6	302 μM (± 5)	2.2	MMP-9
7	2.7 μM (± 0.2)	8	587 μM (± 7)	202	MMP-9
7	0.075 μM (± 0.005)	8	84 μM (± 1)	1120	MMP-8

QIC₅₀ = quotient IC₅₀ = IC₅₀ proinhibitor/IC₅₀ inhibitor.