Table 2.

Functional and Physical Measurements of Hearts

	WT	cMyBP-C (tWT)	cMyBP-C (t3SA)	KO
n	6	5	5	6
HR(beats/min)	412±25	424±57	427±45	453±59
HR (beats/min) w/Dobutamine	615±31†	673±35†	651±30†	652±23†
LVIDd (mm)	3.7±0.1	4.0±0.1	4.0±0.1	4.2±0.2
LVIDs (mm)	2.6±0.2‡	3.0±0.2	3.2±0.1	3.5±0.2*
PWd (mm)	0.8±0.1‡	1.0±0.1‡	1.5±0.1*	1.3±0.1*
PWs (mm)	1.0±0.1‡	1.2±0.1‡	1.6±0.1*	1.5±0.1*
IVRT (msec)	15.3±1.3‡	16.0±1.0‡	22.5±1.6*	24.8±1.4*
E/e’	10.7±1.7‡	18.1±2.1‡	30.1±3.9*	30.7±2.8*
FS (%)	30.3±2.8‡	24.6±2.5	20.5±1.3*	17.2±1.2*
FS (%) w/Dobutamine	55.3±5.0‡,†	47.3±3.5‡,†	38.1±1.7*,‡,†	24.1±2.2*,†
EF (%)	49.8±3.2‡	46.1±3.0	38.6±2.7	35.2±3.0*
EF(%) w/Dobutamine	91.0±1.0‡,†	88.6±1.8‡,†	74.7±3.0*,‡,†	55.8±5.7*,†
n	10	11	12	5
Heart/Body (mg/g)	5.3±0.1‡	5.8±0.2‡	7.3±0.1*	7.2±0.3*

HR=heart rate, LVIDd=left ventricular inner diameter in diastole, LVIDs=LVID in systole, PWd=posterior wall thickness in diastole, PWs=PW in systole, FS=fractional shortening, EF=ejection fraction, IVRT=isovolumetric relaxation time, E/e’=ratio of peak blood in-flow Doppler at mitral valve to peak tissue movement Doppler at mitral valve annulus.

^*denotes p<0.05 vs. WT

^‡denotes p<0.05 vs KO

^†denotes p<0.05 after dobutamine treatment in comparison to baseline.