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. Author manuscript; available in PMC: 2010 May 11.

Published in final edited form as: Antivir Ther. 2010;15(1):83–90. doi: 10.3851/IMP1488

Table 4c. Pharmacokinetic Parameters-Geometric Mean Ratios (90% CI) (N=18).

Nevirapine (NVP) Plasma PK Parameter Ratios

NVP	PK Parameter	GT/GL	GT/TL	GL/TL
All (n=18)	C_max,ss	1.02 (0.88, 1.18)	0.97 (0.82, 1.15)	0.95 (0.78, 1.16)
All (n=18)	AUC_6hr,ss	1.02 (0.88, 1.18)	0.99 (0.84, 1.15)	0.97 (0.81, 1.16)
Group 1 (n=6)	C_max,ss	1.09 (0.76, 1.55)	0.72 (0.62, 0.82)^*	0.66 (0.43, 1.00)
Group 1 (n=6)	AUC_6hr,ss	1.13 (0.80, 1.60)	0.72 (0.64, 0.82)^*	0.64 (0.46, 0.89)^*
Group 2 (n=6)	C_max,ss	1.02 (0.94, 1.11)	1.07 (0.86, 1.34)	1.05 (0.89, 1.25)
Group 2 (n=6)	AUC_6hr,ss	1.01 (0.94, 1.08)	1.07 (0.89, 1.29)	1.06 (0.89, 1.27)
Group 3 (n=6)	C_max,ss	0.97 (0.75, 1.24)	1.18 (0.82, 1.71)	1.22 (0.96, 1.57)
Group 3 (n=6)	AUC_6hr,ss	0.93 (0.74, 1.17)	1.23 (0.91, 1.67)	1.32 (1.12, 1.56)^*

^*

p<0.03