Skip to main content
. 2010 May 15;24(10):1059–1072. doi: 10.1101/gad.1907510

Figure 3.

Figure 3.

GTML tumors represent two distinct, aggressive MB histologies. (A) Tumor cells of classic histology (black arrowhead) were similar in size to mature granule cells in the IGL (white arrowhead). (B) When compared with classic tumors, LCA tumors exhibited increased nuclear-to-cytoplasmic ratios (black arrowhead), polygonal cell morphology (white arrowhead), and high levels of anaplasia. Invasion was prominent in LCA tumors, with disruption of molecular layer, Purkinje layer, and IGL (ML, PL, and IGL respectively; black arrows). (C) Inset from A shows detail of small, round, blue cells of the classic histology. (D) Inset from B shows detail of large, angular, pleiomorphic LCA cells. (E,F) Immunohistochemical staining for the proliferative marker Ki67 shows strong staining in both classic and LCA GTML tumors, suggesting aggressive tumor growth. (G,H) Immunohistochemical staining for the marker of apoptosis, cleaved Caspase-3 (Cl-Caspase-3), shows positive staining in both classic and LCA GTML tumors, respectively. All pictures except inset (1000×) are shown at 400× magnification.