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Palmitoylation and prenylation are each essential for NRAS leukemogenesis in vivo. (A) Kaplan-Meier plot of cumulative survival of recipient mice transplanted with BM cells infected by NRASD12, NRASD12C181S, or NRASD12C186S containing retroviruses, or the MiG vector. (B) FACS analysis of GFP+ cells in peripheral blood of NRASD12, NRASD12C181S, NRASD12C186S, or GFP vector bone marrow transduction and transplantation mice.
