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. 2010 May 10;207(5):983–997. doi: 10.1084/jem.20092437

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© 2010 Li et al.

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Figure 7. — Rnf8 is a novel tumor suppressor. (A) Kaplan-Meier tumor-free survival analysis for cohorts of WT (n = 28), Rnf8^+/− (n = 29), and Rnf8^−/− (n = 22) mice. Mice were monitored for survival for 465 d. A log-rank test was used for statistical analysis. There was a statistically significant difference between WT and Rnf8^−/− curves (P < 0.0005) and between Rnf8^+/− and Rnf8^−/− curves (P < 0.01). (B and C) Sarcoma invading soft tissues, including skeletal muscle, adipose tissue, and a peripheral nerve, is shown (B). High magnification shows that the tumor is poorly differentiated and has a high proliferative index and atypical mitosis (C). (D) Malignant transformation of the mammary gland with a multinodular growth pattern and invasion into adjacent connective tissues. The tumor is well vascularised and shows no necrosis. (E) A higher magnification shows that tumor cells are growing in small groups, with prominent mitosis and invasion. (F) A tumor composed of small cells with round, sometimes eccentric nuclei and small cytoplasm, is compatible with a lymphoma of B cell origin. (G) Despite its well differentiated appearance, this tumor aggressively infiltrates the periportal areas of the liver. Bars: (B) 100 µm; (C, E, and F) 25 µm; (D) 250 µm; (G) 50 µm.