Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 May 10;207(5):1045–1056. doi: 10.1084/jem.20100050

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 Allen et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 6. — NLRP3 mediates gastrointestinal tumorigenesis in the CAC model. (A) Endoscopic analysis of mice during week 6 of the recurring CAC model. (B) Macroscopic polyps were quantified in indicated mice. (C) Size and weight of representative macroscopic polyps from indicated mice. (D) Composite HAI scores. (E–G) Distal colon hyperplasia (E), dysplasia (F), and area involved with disease (G). Data are representative of three independent experiments. The symbol # indicates P < 0.05 between the AOM/mock and AOM/DSS-treated WT; * and ** indicate P < 0.05 and P < 0.01, respectively, between the Nlrp3^−/− and WT mice. WT AOM, n = 3; WT, n = 10; Nlrc4^−/−, n = 3; Nlrp3^−/−, n = 6.