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. 2010 May 3;189(3):541–556. doi: 10.1083/jcb.200909113

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© 2010 Schoumacher et al.

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Figure 4. — Lamellipodial and filopodial markers are present in invadopodia. (A and B) Immunofluorescence analysis in the gelatin degradation assay. (top left) Fluorescently labeled gelatin. (top right) Actin revealed by phalloidin-Cy3. (bottom left) ABP as indicated. (bottom right) Merged image of ABP (green) and actin. Insets show higher magnification images of the boxed regions. (A) ABPs associated with lamellipodia revealed by immunostaining (p34 subunit of Arp2/3 complex) or by expression of GFP fusion proteins (VASP and α-actinin) in MDA-MB-231 cells. (B) ABPs associated with filopodia visualized by expression of GFP fusion proteins (T-fimbrin in MDA-MB-231 cells; fascin and myosinX in MDA-MB-435 cells). Bars, 5 µm.