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. 2010 May 3;189(3):589–600. doi: 10.1083/jcb.201003007

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© 2010 Mendez et al.

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Figure 1. — NCad regulates spine morphology and PSD size. (A) Dendritic segments from pyramidal CA1 neurons transfected with EGFP (Ctrl), EGFP + WT-NCad (NCad), or EGFP + the mutant Δ390-NCad (Δ390). Note the increased proportion of thin, immature-type spines in the cell transfected with Δ390-NCad. Boxes show the corresponding enlarged dendritic segments below. (B) Cumulative distribution of spine head width in the three conditions, indicating a shift to the left in Δ390-NCad cells (n = 5; P < 0.001; one-way ANOVA). (C) PSD-95–EGFP puncta in cells transfected with PSD-95–EGFP (Ctrl), PSD-95–EGFP + NCad (NCad), or PSD-95–EGFP + Δ390-NCad (Δ390). (D) Cumulative distribution of the size of PSD-95–EGFP puncta in the three conditions. Note the shift to the left in Δ390-NCad–transfected cells (n = 4; P < 0.001; one-way ANOVA). Bars: (A, top) 50 µm; (A, bottom) 2 µm; (C) 1 µm.