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. 2010 May 3;189(3):589–600. doi: 10.1083/jcb.201003007

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© 2010 Mendez et al.

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Figure 2. — Regulation of spine ultrastructure by NCad. (A) Illustrations of dendritic spines (arrows) visualized on consecutive sections obtained from a dendritic segment of a pyramidal CA1 neuron transfected with EGFP + Δ390-NCad (Δ390) or EGFP + NCad (NCad). The transfected dendritic segment is revealed by anti-EGFP immunostaining. (B) 3D reconstruction of two dendritic segments obtained from cells transfected with EGFP + Δ390-NCad or EGFP + NCad. Note the differences in size of spine heads and PSD areas (red). (C and D) Quantitative analysis of spine head volume and PSD area obtained from 3D-reconstructed dendritic segments of CA1 pyramidal neurons transfected with EGFP (Ctrl), EGFP + NCad, or EGFP + Δ390-NCad. Data are mean ± SEM of three experiments per condition (110, 58, and 127 reconstructed spines analyzed; *, P < 0.05; **, P < 0.01; ***, P < 0.001; Mann-Whitney U test). Bars: (A) 1 µm; (B) 2 µm.