Table 1.

Glucose infusion rates, peak plasma hormone concentrations, and extracellular GABA concentrations

	aECF	100 mM d-Glucose	100 mM l-Glucose	aECF + BIC
Glucose infusion rate, mg·kg–1·min–1	10 ± 1	14 ± 1*	11.0 ± 1	7 ± 1*
Glucagon, pg/ml	344 ± 21	192 ± 39*	406 ± 84	904 ± 82*
Epinephrine, pg/ml	4,585 ± 434	3,022 ± 483*	4,883 ± 881	7,633 ± 476*
GABA, nM	11 ± 3‡	25 ± 4	10 ± 2†	12 ± 6‡

Data are presented as means ± SE. Glucose infusion rates, peak plasma hormone concentrations, and extracellular GABA concentrations during the hypoglycemic clamping period for animals microdialyzed with artificial extracellular fluid (aECF) and microinjected with aECF (A), microdialyzed with 100 mM d-glucose and microinjected with aECF (B), microdialyzed with 100 mM l-glucose and microinjected with aECF (C), or microdialyzed with aECF and microinjected with bicuculline (aECF + BIC; D).

^*P < 0.05 vs. aECF controls;

^†P < 0.05 vs. baseline GABA concentrations;

^‡P < 0.03 vs. baseline GABA concentrations.