Table 2.
Amplitude and duration of APs and OGB-5N transients from control, mdx, and utr−/−/mdx fibers
| AP |
ΔF/F |
|||||
|---|---|---|---|---|---|---|
| Mice Strain | n | Amplitude, mV | FDHM, ms | Amplitude | FDHM, ms | Peak Ca2+ Release Flux, μM/ms |
| WT | 15 | 124.8 ± 7.1 | 2.17 ± 0.48 | 0.79 ± 0.19 | 1.57 ± 0.18 | 242.4 ± 58.4 |
| mdx | 11 | 122.6 ± 9.7 | 2.48 ± 0.68 | 0.49 ± 0.10* | 1.80 ± 0.30* | 150.3 ± 32.1* |
| utr−/−/mdx | 14 | 116.7 ± 9.5* | 3.15 ± 1.25* | 0.54 ± 0.15* | 1.74 ± 0.29 | 165.7 ± 47.3* |
Values are means ± SD; n is the number of mice. APs, action potentials; FDHM, full duration at half-maximum amplitude; OGB-5N, Oregon Green 488 BAPTA-5N.1
*
P < 0.05 ANOVA unpaired t-test comparison with WT values.