Fig. 5.

Curcumin inhibits collagen secretion from IPF fibroblasts. Serum-starved fibroblasts from lungs of patients with IPF (n = 3) were pretreated with curcumin (5 and 10 μM) for 2 h and then incubated with fresh medium in the absence (A) or presence (B) of TGF-β (6 ng/ml) for 24 h. Soluble collagen levels were measured by Sircol assay. Values indicated were normalized to control for each experiment. *P < 0.05 vs. 0 μM.