Fig. 4.

Sections of hypertrophied kidneys from rats subjected to nephrectomy by right nephrectomy and either ligation of 2 of 3 branches of the left renal artery (A, D, G, and H) or surgical excision of both poles of the left kidney (B, E, and I) and sections of intact kidneys of spontaneously hypertensive stroke prone (SHR-SP) rat (C, F, and J). Kidneys were obtained ∼8 wk after nephrectomy or after a comparable period of observation from SHR-SP rats. For the rats from which these sections were obtained, the averaged systolic blood pressures measured by radio telemetry over a 4-wk period preceding death were (in mmHg) nephrectomy (infarction) 214; nephrectomy (excision) 133; and SHR-SP 214. At death, kidneys were perfused with Karnovsky's fixative. Paraffin-embedded sections were stained with hematoxylin and eosin. A–C: micrographs to show presence or absence of tubulointerstitial fibrosis. D–F: micrographs to show presence or absence of occlusive arteriolosclerosis (circled). G–J: micrographs to show presence or absence of tubules with regenerative epithelium (star) and acute injury with apoptotic cells (asterisk). Original magnifications: ×100 (A–C); ×600 (D–F); ×400 (G, I, and J). H: magnified view of tubule marked with small asterisk in G. Unpublished archival material from Bidani-Griffin laboratories was evaluated by M. Venkatachalam. This material is related to but not derived from published work that examined the effects of hypertension alone, renal ablation alone or renal ablation with hypertension on the development of glomerular pathology (19, 56, 59).