Fig. 1.

Effect of methylprednisolone (MP) treatment on (ASBT) in villus cells from the normal and chronically inflamed ileum. Na-dependent taurocholate (tauro) uptake is defined as taurocholate uptake in the presence of extracellular Na minus that in the absence of Na. Y-axis labeling is the same for A and B. Statistical comparisons are made of uptakes of different conditions for each time point. A: Na-dependent bile acid uptake as a function of time in villus cells from control rabbits. This uptake is significantly increased at all time points measured in villus cells from MP-treated normal rabbits. B: in villus cells from the chronically inflamed ileum, Na-dependent taurocholate uptake was significantly inhibited. Treatment of rabbits with chronic ileal inflammation with MP almost completely reversed the inhibition of Na-dependent taurocholate uptake. prot, protein.