Table 1.

Indexes of LV dysfunction and severity of heart failure in wild-type and MnSOD-deficient animals

	SHAM		HF
	WT	MnSOD+/−	WT	MnSOD+/−
Body wt, g	21.4 ± 1.2	21.0 ± 0.6	21.9 ± 0.6	21.3 ± 0.6
LWW/BW	8.4 ± 0.7	8.1 ± 0.6	7.9 ± 0.1	9.3 ± 0.6
HWW/BW	5.8 ± 0.6	5.3 ± 0.5	7.0 ± 0.2‡	7.3 ± 0.4‡
Infarct size,* %			51 ± 7	55 ± 4
Cardiac output,† μl/min	12.6 ± 0.3	10.1 ± 2.4	9.4 ± 2.0	12.2 ± 1.6
EF,† %	68 ± 9	66 ± 7	19 ± 4‡	20 ± 2‡

Values are means ± SE. HF, heart failure; WT, wild type; MnSOD^+/−, manganese superoxide dismutase deficient; LWW/BW, lung wet weight-to-body weight ratio; HWW/BW, heart wet weight-to-body weight ratio; EF: ejection fraction.

^* Measurements made histologically, n = 4–5 mice/group,

^† Measurements derived from echocardiography, n = 4–5 mice/group.

^‡ P < 0.05 vs. sham-operated animals within the same genotype group.