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. 2010 Mar 12;298(5):H1565–H1570. doi: 10.1152/ajpheart.00146.2010

Fig. 1.

Fig. 1.

Regulation of gene expression in skeletal muscle of ANG II-infused wild-type and myosin light chain (MLC)/mIgf-1 mice. ANG II or saline minipumps were implanted to FVB or MLC/mIgf-1 mice, and gastrocnemius muscles were collected 1, 4, and 7 days after implantation. Gastrocnemius muscle weight of each animal was measured 7 days after minipump implantation (E), and atrogin-1 (A), muscle ring finger-1 (MuRF-1; B), IGF-1 (C), and IGF-1 receptor (IGF-1R; D) expression was quantified by quantitative RT-PCR on days 1, 4, and 7 of infusion. Gastrocnemius muscles of FVB and MLC/mIgf-1 mice were collected 1 day after ANG II or saline infusion, and atrogin-1 (F) and MuRF-1 (G) expression was measured by quantitative RT-PCR. Means are ± SE; n = 5 to 6. *P < 0.05; **P < 0.01.