Fig. 5.
Influence of [pyruvate] on hemodynamic performance of the isolated working heart. “Pre” and “Post” refer to measurements immediately before and 5 min after switching to 6, 10, 15, or 25 mM pyruvate, respectively. Within the 1st min of switchover, there was a variable decrease in developed pressure that recovered quickly. Heart rate, developed pressure, and O2 consumption were not altered substantially by exposure to graded [pyruvate]. Data are means ± SD. All pre vs. post data sets were not significantly different from each other for heart rate and myocardial O2 consumption (MV̇o2). Developed pressure decreased significantly with all concentrations included in the repeated-measures model (pre vs. post difference 13.3 mmHg, 95% confidence interval, 8.8–17.9 mmHg, P < 0.0001). However, no significant pre vs. post differences were observed within any concentration, analyzed with Bonferroni-Holm adjusted multiple comparisons.