Table 1.
Reperfusion |
||||
---|---|---|---|---|
Parameter | Baseline | Ischemia (15 min) | 10 min | 180 min |
HR, beats/min | ||||
Males | 268 ± 4 | 259 ± 4 | 250 ± 4‡ | 246 ± 3‡ |
Females | 243 ± 6* | 253 ± 7 | 250 ± 9 | 224 ± 3*‡ |
Oophorectomized females | 245 ± 10* | 236 ± 5* | 241 ± 8 | 227 ± 7* |
MAP, mmHg | ||||
Males | 63 ± 2 | 54 ± 2‡ | 54 ± 2‡ | 49 ± 2‡ |
Females | 77 ± 3* | 67 ± 3*‡ | 62 ± 4‡ | 58 ± 2*‡ |
Oophorectomized females | 75 ± 4* | 61 ± 3 | 64 ± 3‡ | 63 ± 3* |
LVEDP, mmHg | ||||
Males | 2.2 ± 0.4 | 5.9 ± 0.9‡ | 5.2 ± 0.6‡ | 4.9 ± 0.8‡ |
Females | 2.7 ± 0.5 | 3.8 ± 0.8 | 4.2 ± 0.8 | 3.8 ± 0.9 |
Oophorectomized females | 2.4 ± 0.5 | 5.6 ± 0.9‡ | 3.8 ± 0.4 | 3.6 ± 0.5 |
+dP/dtmax, mmHg/s | ||||
Males | 1977 ± 63 | 1636 ± 69‡ | 1601 ± 84‡ | 1415 ± 72‡ |
Females | 2367 ± 137* | 2235 ± 89* | 2087 ± 186* | 1986 ± 168* |
Oophorectomized females | 1734 ± 68† | 1544 ± 70† | 1593 ± 95 | 1583 ± 142 |
RPP/1,000, mmHg·beats·min−1 | ||||
Males | 20.5 ± 0.6 | 17.0 ± 0.6‡ | 16.7 ± 0.6‡ | 18.2 ± 2.6 |
Females | 19.7 ± 0.9 | 17.7 ± 1.0‡ | 16.6 ± 1.3‡ | 14.6 ± 0.8‡ |
Oophorectomized females | 19.6 ± 2.1 | 15.9 ± 0.7 | 16.2 ± 1.2 | 14.9 ± 0.8 |
Values are means ± SE. HR, heart rate; MAP, mean arterial pressure; LVEDP, left ventricular (LV) end-diastolic pressure; +dP/dtmax, maximal rate of LV pressure increase over time; RPP, rate-pressure product.
P < 0.05 vs. males at that time point;
P < 0.05 vs. females at that time point;
P < 0.05 vs. baseline.