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Deficiency in MKP-1 decreased NO production in the lungs. Accumulation of nitrite/nitrate (NOx) in the lungs from WT (black bars) and Mkp-1−/− (gray bars) mice under normoxia or hypoxia was measured using a chemiluminescence NO analyzer and normalized to lung protein concentration (nmol/mg protein); n = 5–6 in each group. #P < 0.05, Mkp-1−/− different from WT same condition.
