Table 1.
Genetic association of genetic markers in SORL1 with dementia/AD risk and quantitative traits
| Marker | Group | Genotypes | dementia | AD only | AB42 p | Tau p | ||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | ||||||
| rs668387 | cases | 279 (219) | 723 (572) | 423 (353) | 0.97(0.87–1.07) | 0.95(0.86–1.06) | 0.36 (639) | 0.76 (655) |
| controls | 444 | 1008 | 595 | p = 0.50 | p = 0.35 | |||
| AA | AG | GG | ||||||
| rs689021 | cases | 274 (213) | 762 (606) | 459 (383) | 0.97(0.88–1.07) | 0.96(0.87–1.06) | 0.52 (674) | 0.75 (691) |
| controls | 437 | 1051 | 649 | p = 0.59 | p = 0.39 | |||
| AA | AG | GG | ||||||
| rs641120 | cases | 282 (221) | 780 (624) | 471 (393) | 0.97(0.88–1.07) | 0.96(0.87–1.06) | 0.45 (704) | 0.75 (721) |
| controls | 448 | 1070 | 666 | p = 0.55 | p = 0.36 | |||
| AA | AC | CC | ||||||
| rs2070045 | cases | 839 (677) | 593 (480) | 101 (80) | 0.99(0.88–1.10) | 0.96(0.86–1.08) | 0.57 (705) | 0.77 (722) |
| controls | 1198 | 841 | 142 | p = 0.82 | p = 0.52 | |||
| AA | AT | TT | ||||||
| rs3824968 | cases | 159 (134) | 702 (559) | 666 (538) | 1.04(0.94–1.15) | 1.08(0.97–1.19) | 0.77 (700) | 0.41 (717) |
| controls | 229 | 967 | 988 | p = 0.43 | p = 0.16 | |||
| AA | AG | GG | ||||||
| rs2282649 | cases | 147 (123) | 687 (554) | 693 (554) | 1.06(0.95–1.17) | 1.10(0.99–1.22) | 0.80 (702) | 0.43 (719) |
| controls | 214 | 924 | 1040 | p = 0.30 | p = 0.078 | |||
Genotype counts are shown for dementia and (AD alone). Odds ratios (95% CI) and significances for case-control association in dementia and AD were determined using alternating logistic regression to account for sibling structure (as described in the main text). Significance for quantitative traits (number of individuals) was performed using ANOVA in unrelated individuals.