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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cell Metab. 2009 Aug;10(2):148–159. doi: 10.1016/j.cmet.2009.07.001

Figure 2. Whole body PET images of mice and rats reveal that leptin is taken up in the cortex of the kidney.

Figure 2

The images are overexposed to reveal areas with a lower level of uptake. A) Whole body PET maximum intensity projection (MIP) image of a leptin deficient (ob/ob) mouse injected with 68Ga-DOTA-leptin. Renal uptake of leptin in ob/ob mice is 65.1% ± 3.5% while the bladder is only 2.2 ± 0.2% over 30 min. Uptake in other organs is lower than this per volume. B) Whole body PET coronal MIP image of an ob/ob mouse injected with 18F-FBA-leptin, with inset of kidneys with lowered contrast, revealing uptake of the hormone in the renal cortex. C) Whole body PET coronal MIP of a Sprague-Dawley rat injected with 68Ga-DOTA-leptin, with inset with lowered contrast, revealing uptake of the hormone in the cortex of the kidney. D) Simplified diagram of renal anatomy.