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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cell Metab. 2009 Aug;10(2):148–159. doi: 10.1016/j.cmet.2009.07.001

Figure 6. PET imaging study of leptin biodistribution in rhesus macaques.

Figure 6

Images were acquired 10 minutes post injection of 15 MBq 68Ga-DOTA-leptin or 18F-FBA-leptin. A-B) Coronal MIP acquired 10 minutes post injection of 68Ga-DOTA-leptin (A) or 18F-FBA-leptin (B). C) Coronal MIP of a rhesus macaque acquired 10 minutes post injection of 15 MBq 68Ga-DOTA-leptin, with pre-treatment with 1 mg of rhesus leptin 5 minutes before radiotracer injection. D) Coronal PET-CT fusion revealing uptake of the tracer in the cortex of the kidney. E) Sagittal PET-CT fusion revealing uptake of the tracer in the vertebral bodies, sternum, liver, and presence of the tracer in the blood pool. F-H) Axial PET-CT sections through the sphenoid bone of the base of the skull (F), the L4 vertebral body (G), and the sacrum (H). I-J) Time activity curves of 68Ga-DOTA-leptin uptake in the bone marrow (I) and heart (J). The y axis on the TACs represents the % of total injected dose localized to that tissue.